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Laboratory of Biomedical Science

Theme 1: Molecular Mechanisms of Human Disease
Theme 2: Identification of Functional SNPs in noncoding region
Theme 3: Development of New Methods for diagnosis and medical treatment

Curriculum vitae

Name in Full Kazuyuki Yanai
Place of Birth Tokyo, Japan
Nationality Japanese
Present Status Associate Professor,
Laboratory of Biomedical Science,
Division of Molecular Medicine,
Department of Biomolecular Science
Faculty of Science, Toho University
Education BS in Biology, Tsukuba University, Ibaraki, Japan, March, 1992
PhD in Applied Biochemistry, Tsukuba University, March, 1997
Resarch Fellow of the Japan Society for  the Promotion of Science, Institute of Applied Biochemistry, University of Tsukuba, April, 1995 - March, 2000

Resarch Fellow, Department of Genetics,Harvard Medical School, April, 2000 - March, 2002

Resarch Fellow, Department of Gene Diagnostics and Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-September, 2002

Section Head, Division of Gene Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-March, 2007

Associate Professor, Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, April, 2007 to the present time
Award CVEM Young Investigator Award, the first International Symposium of Cardiovascular Endocrinology and Metabolism, 1998

Young Investigator Award, the second American Society of Hypertension-Japan Society of Hypertension Joint Hypertension Symposium, 1998

Okamoto Award, Japan Vascular Disease Research Foundation, 1998

Inoue Resarch Award for Young Scientists, Inoue Foundation for  Science, 1998

Young Investigator Award, Tokyo Hypertension Reserch Society, 2000


Research papers

2011 26. Ito K, Higai K, Sakurai M, Shinoda C, Yanai K, Azuma Y, Matsumoto K.
"Binding of natural cytotoxicity receptor NKp46 to sulfate- and α2,3-NeuAc-containing glycans and its mutagenesis."
Biochem Biophys Res Commun. 2011 Mar 18;406(3):377-82.

PMID: 21329668
2010 25. Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato N, Yanai K.
"Identification and characterization of glucocorticoid receptor-binding sites in the human genome."
J Recept Signal Transduct Res. 2010 Apr;30(2):88-105.

PMID: 20163328
2009 24. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi T, Fujioka A, Yamori Y, Ogihara T and Kato N
"Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population."
Hypertens Res. 2009;32(3):207-13.

PMID: 19262484
2008 23. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N.
"Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q."
J Hum Genet. 2008;53(4):314-24.
PMID: 18259684
22. Tanimoto K, Sugiura A, Kanafusa S, Saito T, Masui N, Yanai K, Fukamizu A.
"A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation."
J Clin Invest. 2008 Mar;118(3):1006-16.
PMID: 18259612
21. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H.
"High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project."
Hum Mol Genet. 2008 Feb 15;17(4):617-27.
PMID: 18003638
2007 20. Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N.
"Search of type 2 diabetes susceptibility gene on chromosome 20q."
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1100-6.
PMID: 17466274
2005 19. Takeuchi F*, Yanai K*, Morii T, Ishinaga Y, Taniguchi-Yanai K, Nagano S, Kato N.
"Linkage disequilibrium grouping of single nucleotide polymorphisms (SNPs) reflecting haplotype phylogeny for efficient selection of tag SNPs."
Genetics. 2005 May;170(1):291-304.
PMID: 15716494
*These authors contributed equally to this work.
18. Watanabe T, Iizuka Y, Liang YQ, Inomata H, Gotoda T, Yanai K, Isobe M, Kato N.
"Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony."
Biochem Biophys Res Commun. 2005 Apr 15;329(3):879-87.
PMID: 15752738
17. Inomata H, Watanabe T, Iizuka Y, Liang YQ, Mashimo T, Nabika T, Ikeda K, Yanai K, Gotoda T, Yamori Y, Isobe M, Kato N.
"Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat."
Hypertens Res. 2005 Mar;28(3):273-81.
PMID: 16097372
2004 16. Mochizuki-Sakisaka R, Dateki M, Ishizuka Y, Yanai K, Matsuda Y, Koga Y, Fukamizu A.
"Structural organization of the mouse neurochondrin gene."
Int J Mol Med. 2004 Sep;14(3):361-6.
PMID: 15289886
15. Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A.
"Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene."
Int J Mol Med. 2004 May;13(5):637-42.
PMID: 15067362
14. Dateki M, Mochizuki R, Yanai K, Fukamizu A.
"Identification of the mouse neurochondrin promoter region and the responsible region for cell type specific gene regulation."
Neurosci Lett. 2004 Feb 12;356(2):107-10.
PMID: 14746875
2003 13. Kato N, Nabika T, Liang YQ, Mashimo T, Inomata H, Watanabe T, Yanai K, Yamori Y, Yazaki Y, Sasazuki T.
"Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model."
Hypertension. 2003 Dec;42(6):1191-7. Epub 2003 Nov 17.
PMID: 14623828
12. Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, Koga Y, Ozawa H, Fukamizu A.
"Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality."
Biochem Biophys Res Commun. 2003 Oct 31;310(4):1219-26.
PMID: 14559245
11. Saito T, Oishi T, Yanai K, Shimamoto Y, Fukamizu A.
"Cloning and characterization of a novel splicing isoform of USF1."
Int J Mol Med. 2003 Aug;12(2):161-7.
PMID: 12851711
2000 10. Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai K, Nishijo N, Shigematsu Y, Horiguchi H, Kasuya Y, Sugiyama F, Yagami K, Murakami K, Fukamizu A.
"Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice."
J Biol Chem. 2000 Jan 7;275(1):5-8.
PMID: 10617578
1999 9. Yanai K, Hirota K, Taniguchi-Yanai K, Shigematsu Y, Shimamoto Y, Saito T, Chowdhury S, Takiguchi M, Arakawa M, Nibu Y, Sugiyama F, Yagami K, Fukamizu A.
"Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor."
J Biol Chem. 1999 Dec 3;274(49):34605-12.
PMID: 10574924
8. Ishiduka Y, Mochizuki R, Yanai K, Takatsuka M, Nonomura T, Niida S, Horiguchi H, Maeda N, Fukamizu A.
"Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin."
Biochim Biophys Acta. 1999 May 6;1450(1):92-8.
PMID: 10231559
7. Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A, Murakami K.
"Molecular cloning and expression of human neurochondrin-1 and -2."
Biochim Biophys Acta. 1999 Sep 3;1446(3):397-402.
PMID: 10524216
Erratum in: Biochim Biophys Acta 2000 Feb 29;1490(3):367-8.
PMID: 10684983
6. Kawahara K, Watanabe S, Ohshima T, Soejima Y, Oishi T, Aratani S, Nakata M, Shibata M, Inoue K, Amano T, Fujii R, Yanai K, Hagiwara M, Fukamizu A, Maruyama I, Nakajima T.
"Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells."
Biochem Biophys Res Commun. 1999 Dec 20;266(2):417-24.
PMID: 10600518
1997 5. Yanai K, Saito T, Hirota K, Kobayashi H, Murakami K, Fukamizu A.
"Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity"
J Biol Chem. 1997 Nov 28;272(48):30558-62.
PMID: 9374551
4. Yanai K, Murakami K, Fukamizu A.
"ATF-like element contributes to hepatic activation of human angiotensinogen promoter."
Biochem Biophys Res Commun. 1997 Aug 8;237(1):158-62.
PMID: 9266849
3. Yanai K, Matsuyama S, Murakami K, Fukamizu A.
"Differential action of AGCF2 upon cell type-dependent expression of human angiotensinogen gene"
FEBS Lett. 1997 Jul 28;412(2):285-9.
PMID: 9256236
1996 2. Yanai K, Nibu Y, Murakami K, Fukamizu A.
"A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene."
J Biol Chem. 1996 Jul 5;271(27):15981-6.
PMID: 8663141
1995 1. Shimada S, Yanai K, Takahashi S, Murakami K, and Fukamizu A
"Identification of Two Distinct Sp1- and RBF-1-like Nuclear Factors that Bind to the Upstream Region of the Human Angiotensinogen Promoter"
Endocrine 3, 543-547. (1995)


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Department of Biomolecular Science,
Faculty of Science, Toho University
Laboratory of Biomedical Science

Laboratory of Biomedical Science
Laboratory of Biomedical Science


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 Department of Biomolecular Science,
 Faculty of Science, Toho University
 Miyama2-2-1, Funabashi, Chiba, 274-8510 Japan

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