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 Laboratory | Curriculum vitae| Research papers | Laboratory Photos | How to Contact Us | |
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 Laboratory of Biomedical Science |
Theme 1: Molecular Mechanisms of Human Disease
Theme 2: Identification of Functional SNPs in noncoding region
Theme 3: Development of New Methods for diagnosis and medical treatment
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| Curriculum vitae |
| Name in Full |
Kazuyuki Yanai |
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| Place of Birth |
Tokyo, Japan |
| Nationality |
Japanese |
| e-mail |
drkazu_kansou@hotmail.com |
| Present Status |
Associate Professor,
Laboratory of Biomedical Science,
Division of Molecular Medicine,
Department of Biomolecular Science,
Faculty of Science, Toho University |
| Education |
BS in Biology, Tsukuba University, Ibaraki, Japan, March, 1992
PhD in Applied Biochemistry, Tsukuba University, March, 1997 |
Academic
Experience |
Resarch Fellow of the Japan Society for the Promotion of Science, Institute of
Applied Biochemistry, University of Tsukuba, April, 1995 - March, 2000
Resarch Fellow, Department of Genetics,Harvard Medical School, April, 2000 - March, 2002
Resarch Fellow, Department of Gene Diagnostics and Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-September, 2002
Section Head, Division of Gene Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-March, 2007
Associate Professor, Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, April, 2007 to the present time
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| Award |
CVEM Young Investigator Award, the first International Symposium of Cardiovascular Endocrinology and
Metabolism, 1998
Young Investigator Award, the second American Society of Hypertension-Japan Society of Hypertension
Joint Hypertension Symposium, 1998
Okamoto Award, Japan Vascular Disease Research Foundation, 1998
Inoue Resarch Award for Young Scientists, Inoue Foundation for Science, 1998
Young Investigator Award, Tokyo Hypertension Reserch Society, 2000 |
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| Research papers |
| 2008年 |
23. |
Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi
Y, Yasuda K, Shirasawa S, Sasazuki T, Kato
N.
"Search for type 2 diabetes susceptibility
genes on chromosomes 1q, 3q and 12q."
J Hum Genet. 2008;53(4):314-24.
PMID: 18259684 |
| 22. |
Tanimoto K, Sugiura A, Kanafusa S, Saito
T, Masui N, Yanai K, Fukamizu A.
"A single nucleotide
mutation in the
mouse renin promoter disrupts
blood pressure
regulation."
J Clin Invest. 2008 Mar;118(3):1006-16.
PMID: 18259612 |
| 21. |
Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K,
Takeuchi F, Mano H, Yasunami
M, Kimura A,
Kita Y, Ueshima H, Nakayama
T, Soma M, Hata
A, Fujioka A, Kawano Y,
Nakao K, Sekine A,
Yoshida T, Nakamura Y,
Saruta T, Ogihara
T, Sugano S, Miki T, Tomoike
H.
"High-density association
study and
nomination of susceptibility
genes for hypertension
in the Japanese National
Project."
Hum Mol Genet. 2008 Feb 15;17(4):617-27.
PMID: 18003638 |
| 2007年 |
20. |
Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S,
Takeda N, Kaburagi Y, Yasuda
K, Shirasawa
S, Sasazuki T, Kato N.
"Search of type 2
diabetes susceptibility
gene on chromosome 20q."
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1100-6.
PMID: 17466274 |
| 2005年 |
19. |
Takeuchi F*, Yanai K*, Morii T, Ishinaga Y, Taniguchi-Yanai K,
Nagano S, Kato N.
"Linkage disequilibrium
grouping of
single nucleotide polymorphisms
(SNPs) reflecting
haplotype phylogeny for
efficient selection
of tag SNPs."
Genetics. 2005 May;170(1):291-304.
PMID: 15716494
*These authors contributed
equally to this
work. |
| 18. |
Watanabe T, Iizuka Y, Liang YQ, Inomata H,
Gotoda T, Yanai K, Isobe M, Kato N.
"Evaluation of insulin
resistance linkage
to rat chromosome 4 in
SHR of a Japanese
colony."
Biochem Biophys Res Commun. 2005 Apr 15;329(3):879-87.
PMID: 15752738 |
| 17. |
Inomata H, Watanabe T, Iizuka Y, Liang YQ,
Mashimo T, Nabika T, Ikeda
K, Yanai K, Gotoda T, Yamori Y, Isobe M, Kato N.
"Identification of
quantitative trait
loci for cardiac hypertrophy
in two different
strains of the spontaneously
hypertensive
rat."
Hypertens Res. 2005 Mar;28(3):273-81.
PMID: 16097372 |
| 2004年 |
16. |
Mochizuki-Sakisaka R, Dateki M, Ishizuka
Y, Yanai K, Matsuda Y, Koga Y, Fukamizu A.
"Structural organization
of the mouse
neurochondrin gene."
Int J Mol Med. 2004 Sep;14(3):361-6.
PMID: 15289886 |
| 15. |
Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A.
"Finb, a multiple
zinc finger protein,
represses transcription
of the human angiotensinogen
gene."
Int J Mol Med. 2004 May;13(5):637-42.
PMID: 15067362 |
| 14. |
Dateki M, Mochizuki R, Yanai K, Fukamizu A.
"Identification of
the mouse neurochondrin
promoter region and the
responsible region
for cell type specific
gene regulation."
Neurosci Lett. 2004 Feb 12;356(2):107-10.
PMID: 14746875 |
| 2003年 |
13. |
Kato N, Nabika T, Liang YQ, Mashimo T, Inomata
H, Watanabe T, Yanai K, Yamori Y, Yazaki Y, Sasazuki T.
"Isolation of a chromosome
1 region
affecting blood pressure
and vascular disease
traits in the stroke-prone
rat model."
Hypertension. 2003 Dec;42(6):1191-7. Epub
2003 Nov 17.
PMID: 14623828 |
| 12. |
Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, Koga
Y, Ozawa H, Fukamizu A.
"Targeted disruption
of the neurochondrin/norbin
gene results in embryonic
lethality."
Biochem Biophys Res Commun. 2003 Oct 31;310(4):1219-26.
PMID: 14559245 |
| 11. |
Saito T, Oishi T, Yanai K, Shimamoto Y, Fukamizu A.
"Cloning and characterization
of a novel
splicing isoform of USF1."
Int J Mol Med. 2003 Aug;12(2):161-7.
PMID: 12851711 |
| 2000年 |
10. |
Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai
K, Nishijo N, Shigematsu
Y, Horiguchi H,
Kasuya Y, Sugiyama F, Yagami
K, Murakami
K, Fukamizu A.
"Renin-dependent cardiovascular
functions
and renin-independent blood-brain
barrier
functions revealed by renin-deficient
mice."
J Biol Chem. 2000 Jan 7;275(1):5-8.
PMID: 10617578 |
| 1999年 |
9. |
Yanai K, Hirota K, Taniguchi-Yanai K, Shigematsu
Y, Shimamoto Y, Saito T,
Chowdhury S, Takiguchi
M, Arakawa M, Nibu Y, Sugiyama
F, Yagami
K, Fukamizu A.
"Regulated expression
of human angiotensinogen
gene by hepatocyte nuclear
factor 4 and chicken
ovalbumin upstream promoter-transcription
factor."
J Biol Chem. 1999 Dec 3;274(49):34605-12.
PMID: 10574924 |
| 8. |
Ishiduka Y, Mochizuki R, Yanai K, Takatsuka M, Nonomura T, Niida S, Horiguchi
H, Maeda N, Fukamizu A.
"Induction of hydroxyapatite
resorptive
activity in bone marrow
cell populations
resistant to bafilomycin
A1 by a factor with
restricted expression to
bone and brain,
neurochondrin."
Biochim Biophys Acta. 1999 May 6;1450(1):92-8.
PMID: 10231559 |
| 7. |
Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A, Murakami K.
"Molecular cloning
and expression of
human neurochondrin-1 and
-2."
Biochim Biophys Acta. 1999 Sep 3;1446(3):397-402.
PMID: 10524216
Erratum in: Biochim Biophys Acta 2000 Feb 29;1490(3):367-8.
PMID: 10684983 |
| 6. |
Kawahara K, Watanabe S, Ohshima T, Soejima
Y, Oishi T, Aratani S,
Nakata M, Shibata
M, Inoue K, Amano T, Fujii
R, Yanai K, Hagiwara M, Fukamizu A, Maruyama I, Nakajima
T.
"Hypernuclear acetylation
in atherosclerotic
lesions and activated vascular
smooth muscle
cells."
Biochem Biophys Res Commun. 1999 Dec 20;266(2):417-24.
PMID: 10600518 |
| 1997年 |
5. |
Yanai K, Saito T, Hirota K, Kobayashi H, Murakami
K, Fukamizu A.
"Molecular variation
of the human angiotensinogen
core promoter element located
between the
TATA box and transcription
initiation site
affects its transcriptional
activity"
J Biol Chem. 1997 Nov 28;272(48):30558-62.
PMID: 9374551 |
| 4. |
Yanai K, Murakami K, Fukamizu A.
"ATF-like element
contributes to hepatic
activation of human angiotensinogen
promoter."
Biochem Biophys Res Commun. 1997 Aug 8;237(1):158-62.
PMID: 9266849 |
| 3. |
Yanai K, Matsuyama S, Murakami K, Fukamizu A.
"Differential action
of AGCF2 upon cell
type-dependent expression
of human angiotensinogen
gene"
FEBS Lett. 1997 Jul 28;412(2):285-9.
PMID: 9256236 |
| 1996年 |
2. |
Yanai K, Nibu Y, Murakami K, Fukamizu A.
"A cis-acting DNA
element located between
TATA box and transcription
initiation site
is critical in response
to regulatory sequences
in human angiotensinogen
gene."
J Biol Chem. 1996 Jul 5;271(27):15981-6.
PMID: 8663141 |
| 1995年 |
1. |
Shimada S, Yanai K, Takahashi S, Murakami K, and Fukamizu A
"Identification of
Two Distinct Sp1-
and RBF-1-like Nuclear
Factors that Bind
to the Upstream Region
of the Human Angiotensinogen
Promoter"
Endocrine 3, 543-547. (1995) |
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Department of Biomolecular Science,
Faculty of Science, Toho University
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Laboratory of Biomedical Science
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Laboratory of Biomedical Science
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Laboratory of Biomedical Science
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10 minutes by bus from Tsudanuma Station on the Sobu Line.
A 10-minute walk from Keisei-Okubo Station on the Keisei Line.
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