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 Laboratory | Curriculum vitae| Research papers | Laboratory Photos | How to Contact Us | |
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 Laboratory of Biomedical Science |
Theme 1: Molecular Mechanisms of Human Disease
Theme 2: Identification of Functional SNPs in noncoding region
Theme 3: Development of New Methods for diagnosis and medical treatment
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| Curriculum vitae |
| Name in Full |
Kazuyuki Yanai |
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| Place of Birth |
Tokyo, Japan |
| Nationality |
Japanese |
| e-mail |
drkazu_kansou@hotmail.com |
| Present Status |
Associate Professor,
Laboratory of Biomedical Science,
Division of Molecular Medicine,
Department of Biomolecular Science,
Faculty of Science, Toho University |
| Education |
BS in Biology, Tsukuba University, Ibaraki, Japan, March, 1992
PhD in Applied Biochemistry, Tsukuba University, March, 1997 |
Academic
Experience |
Resarch Fellow of the Japan Society for the Promotion of Science, Institute of
Applied Biochemistry, University of Tsukuba, April, 1995 - March, 2000
Resarch Fellow, Department of Genetics,Harvard Medical School, April, 2000 - March, 2002
Resarch Fellow, Department of Gene Diagnostics and Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-September, 2002
Section Head, Division of Gene Therapeutics, Reserch Institute, International Medical Center of Japan, April, 2002-March, 2007
Associate Professor, Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, April, 2007 to the present time
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| Award |
CVEM Young Investigator Award, the first International Symposium of Cardiovascular Endocrinology and
Metabolism, 1998
Young Investigator Award, the second American Society of Hypertension-Japan Society of Hypertension
Joint Hypertension Symposium, 1998
Okamoto Award, Japan Vascular Disease Research Foundation, 1998
Inoue Resarch Award for Young Scientists, Inoue Foundation for Science, 1998
Young Investigator Award, Tokyo Hypertension Reserch Society, 2000 |
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| Top |
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| Research papers |
| 2011 |
26. |
Ito K, Higai K, Sakurai M, Shinoda C, Yanai K, Azuma Y, Matsumoto K.
"Binding of natural cytotoxicity receptor NKp46 to sulfate- and α2,3-NeuAc-containing
glycans and its mutagenesis."
Biochem Biophys Res Commun. 2011 Mar 18;406(3):377-82.
PMID: 21329668 |
| 2010 |
25. |
Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta
Y, Serizawa M, Ohshima N, Kato N, Yanai K.
"Identification and characterization
of glucocorticoid receptor-binding sites
in the human genome."
J Recept Signal Transduct Res. 2010 Apr;30(2):88-105.
PMID: 20163328 |
| 2009 |
24. |
Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi T, Fujioka A, Yamori
Y, Ogihara T and Kato N
"Gene-environmental interaction regarding
alcohol-metabolizing enzymes in the Japanese
general population."
Hypertens Res. 2009;32(3):207-13.
PMID: 19262484 |
| 2008 |
23. |
Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi
Y, Yasuda K, Shirasawa
S, Sasazuki T, Kato
N.
"Search for
type 2 diabetes susceptibility
genes on chromosomes
1q, 3q and 12q."
J Hum Genet. 2008;53(4):314-24.
PMID: 18259684 |
| 22. |
Tanimoto K, Sugiura A, Kanafusa S, Saito
T, Masui N, Yanai K, Fukamizu A.
"A single nucleotide
mutation in the
mouse renin promoter
disrupts blood pressure
regulation."
J Clin Invest. 2008
Mar;118(3):1006-16.
PMID: 18259612 |
| 21. |
Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K,
Takeuchi F, Mano
H, Yasunami M, Kimura A,
Kita Y, Ueshima H,
Nakayama T, Soma M, Hata
A, Fujioka A, Kawano
Y, Nakao K, Sekine A,
Yoshida T, Nakamura
Y, Saruta T, Ogihara
T, Sugano S, Miki
T, Tomoike H.
"High-density
association study and
nomination of susceptibility
genes for hypertension
in the Japanese National
Project."
Hum Mol Genet. 2008
Feb 15;17(4):617-27.
PMID: 18003638 |
| 2007 |
20. |
Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S,
Takeda N, Kaburagi
Y, Yasuda K, Shirasawa
S, Sasazuki T, Kato
N.
"Search of type
2 diabetes susceptibility
gene on chromosome
20q."
Biochem Biophys Res
Commun. 2007 Jun
15;357(4):1100-6.
PMID: 17466274 |
| 2005 |
19. |
Takeuchi F*, Yanai K*, Morii T, Ishinaga Y, Taniguchi-Yanai K,
Nagano S, Kato N.
"Linkage disequilibrium
grouping of
single nucleotide
polymorphisms (SNPs) reflecting
haplotype phylogeny
for efficient selection
of tag SNPs."
Genetics. 2005 May;170(1):291-304.
PMID: 15716494
*These authors contributed
equally to this
work. |
| 18. |
Watanabe T, Iizuka Y, Liang YQ, Inomata H,
Gotoda T, Yanai K, Isobe M, Kato N.
"Evaluation
of insulin resistance linkage
to rat chromosome
4 in SHR of a Japanese
colony."
Biochem Biophys Res
Commun. 2005 Apr
15;329(3):879-87.
PMID: 15752738 |
| 17. |
Inomata H, Watanabe T, Iizuka Y, Liang YQ,
Mashimo T, Nabika
T, Ikeda K, Yanai K, Gotoda T, Yamori Y, Isobe M, Kato N.
"Identification
of quantitative trait
loci for cardiac
hypertrophy in two different
strains of the spontaneously
hypertensive
rat."
Hypertens Res. 2005 Mar;28(3):273-81.
PMID: 16097372 |
| 2004 |
16. |
Mochizuki-Sakisaka R, Dateki M, Ishizuka
Y, Yanai K, Matsuda Y, Koga Y, Fukamizu A.
"Structural
organization of the mouse
neurochondrin gene."
Int J Mol Med. 2004
Sep;14(3):361-6.
PMID: 15289886 |
| 15. |
Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A.
"Finb, a multiple
zinc finger protein,
represses transcription
of the human angiotensinogen
gene."
Int J Mol Med. 2004
May;13(5):637-42.
PMID: 15067362 |
| 14. |
Dateki M, Mochizuki R, Yanai K, Fukamizu A.
"Identification
of the mouse neurochondrin
promoter region and
the responsible region
for cell type specific
gene regulation."
Neurosci Lett. 2004
Feb 12;356(2):107-10.
PMID: 14746875 |
| 2003 |
13. |
Kato N, Nabika T, Liang YQ, Mashimo T, Inomata
H, Watanabe T, Yanai K, Yamori Y, Yazaki Y, Sasazuki T.
"Isolation of
a chromosome 1 region
affecting blood pressure
and vascular disease
traits in the stroke-prone
rat model."
Hypertension. 2003
Dec;42(6):1191-7.
Epub
2003 Nov 17.
PMID: 14623828 |
| 12. |
Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, Koga
Y, Ozawa H, Fukamizu
A.
"Targeted disruption
of the neurochondrin/norbin
gene results in embryonic
lethality."
Biochem Biophys Res
Commun. 2003 Oct
31;310(4):1219-26.
PMID: 14559245 |
| 11. |
Saito T, Oishi T, Yanai K, Shimamoto Y, Fukamizu A.
"Cloning and
characterization of a novel
splicing isoform
of USF1."
Int J Mol Med. 2003
Aug;12(2):161-7.
PMID: 12851711 |
| 2000 |
10. |
Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai
K, Nishijo N, Shigematsu
Y, Horiguchi H,
Kasuya Y, Sugiyama
F, Yagami K, Murakami
K, Fukamizu A.
"Renin-dependent
cardiovascular functions
and renin-independent
blood-brain barrier
functions revealed
by renin-deficient mice."
J Biol Chem. 2000
Jan 7;275(1):5-8.
PMID: 10617578 |
| 1999 |
9. |
Yanai K, Hirota K, Taniguchi-Yanai K, Shigematsu
Y, Shimamoto Y, Saito
T, Chowdhury S, Takiguchi
M, Arakawa M, Nibu
Y, Sugiyama F, Yagami
K, Fukamizu A.
"Regulated expression
of human angiotensinogen
gene by hepatocyte
nuclear factor 4 and chicken
ovalbumin upstream
promoter-transcription
factor."
J Biol Chem. 1999
Dec 3;274(49):34605-12.
PMID: 10574924 |
| 8. |
Ishiduka Y, Mochizuki R, Yanai K, Takatsuka M, Nonomura T, Niida S, Horiguchi
H, Maeda N, Fukamizu
A.
"Induction of
hydroxyapatite resorptive
activity in bone
marrow cell populations
resistant to bafilomycin
A1 by a factor with
restricted expression
to bone and brain,
neurochondrin."
Biochim Biophys Acta.
1999 May 6;1450(1):92-8.
PMID: 10231559 |
| 7. |
Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A, Murakami K.
"Molecular cloning
and expression of
human neurochondrin-1
and -2."
Biochim Biophys Acta.
1999 Sep 3;1446(3):397-402.
PMID: 10524216
Erratum in: Biochim Biophys Acta 2000 Feb
29;1490(3):367-8.
PMID: 10684983 |
| 6. |
Kawahara K, Watanabe S, Ohshima T, Soejima
Y, Oishi T, Aratani
S, Nakata M, Shibata
M, Inoue K, Amano
T, Fujii R, Yanai K, Hagiwara M, Fukamizu A, Maruyama I, Nakajima
T.
"Hypernuclear
acetylation in atherosclerotic
lesions and activated
vascular smooth muscle
cells."
Biochem Biophys Res
Commun. 1999 Dec
20;266(2):417-24.
PMID: 10600518 |
| 1997 |
5. |
Yanai K, Saito T, Hirota K, Kobayashi H, Murakami
K, Fukamizu A.
"Molecular variation
of the human angiotensinogen
core promoter element
located between the
TATA box and transcription
initiation site
affects its transcriptional
activity"
J Biol Chem. 1997
Nov 28;272(48):30558-62.
PMID: 9374551 |
| 4. |
Yanai K, Murakami K, Fukamizu A.
"ATF-like element
contributes to hepatic
activation of human
angiotensinogen promoter."
Biochem Biophys Res
Commun. 1997 Aug
8;237(1):158-62.
PMID: 9266849 |
| 3. |
Yanai K, Matsuyama S, Murakami K, Fukamizu A.
"Differential
action of AGCF2 upon cell
type-dependent expression
of human angiotensinogen
gene"
FEBS Lett. 1997 Jul
28;412(2):285-9.
PMID: 9256236 |
| 1996 |
2. |
Yanai K, Nibu Y, Murakami K, Fukamizu A.
"A cis-acting
DNA element located between
TATA box and transcription
initiation site
is critical in response
to regulatory sequences
in human angiotensinogen
gene."
J Biol Chem. 1996
Jul 5;271(27):15981-6.
PMID: 8663141 |
| 1995 |
1. |
Shimada S, Yanai K, Takahashi S, Murakami K, and Fukamizu A
"Identification
of Two Distinct Sp1-
and RBF-1-like Nuclear
Factors that Bind
to the Upstream Region
of the Human Angiotensinogen
Promoter"
Endocrine 3, 543-547.
(1995) |
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Department of Biomolecular Science,
Faculty of Science, Toho University
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Laboratory of Biomedical Science
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Laboratory of Biomedical Science
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Laboratory of Biomedical Science
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10 minutes by bus from Tsudanuma Station on the Sobu Line.
A 10-minute walk from Keisei-Okubo Station on the Keisei Line.
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